Edward Jenner, First vaccination, May 14th,1796

Edward Jenner returned to Berkeley, Gloucester having finished his medical training in London.  (Jenner trained as a surgeon under John Hunter is St George’s Hospital, London) He noticed that milkmaids did not get smallpox. There had also been other experiments in use of cowpox. On May 14, 1796 he took cowpox pus from the hand of milkmaid Sarah Nelmes and placed it into a small cut on James Phipps’ arm. Phipps was Jenner’s gardner’s son. Sarah caught cowpox from a cow called Blossom. Blossom’s skin hangs on the wall of the St George’s Medical School library, now in Tooting, London^.

The first vaccinations were done in the small hut above, which Jenner nicknamed the Temple of Vaccinia. It has just reopened after conservation work supported by public grants. The museum is at The Chantry, once Jenner’s home. It includes the Physic Garden, the Old Cyder House, and the Temple of Vaccinia. It opened in 1985. Jenner gave his inoculations free and did not patent the idea. ~Jenner chose Vaccinia because vacca is the latin word for cow.

After inoculating James Phipps with cowpox, Jenner took some smallpox and put it into a cut on James Phipps arm but Phills did not catch smallpox. This is, perhaps, not the most ethical way to proceed, but Jenner was proved right and now the world has virtually eradicated Small pox.

Inoculation and Variolation

Jenner himself was inoculated with a dose of smallpox as a 13 year old boy. This was called Variolation. Smallpox affected between 20 and 30% of the population, but if a small dose was taken from an infected patient and given to someone without an infection, the chance of death was 1-2%. But the person was prevented from further infection. 30% of people with smallpox died, so given how prevalent smallpox was it was a wise gamble. Lady Mary Wortley Montagu, whose brother died of smallpox, was disfigured by smallpox. In Turkey she witnessed inoculation, and had her 5 year old son inoculated. On its success she promoted inoculation in England.

Jenner’s insight was that cowpox was similar to smallpox, although not deadly, and if given to people it gave immunity to the smallpox, without the risk of death.

First Published May 14th 2026